S3 Transfer Acceleration to faster pull from EC2 in a different AWS Region

Amazon S3 Transfer Acceleration is designed to minimize latency caused by geographic distance between clients and S3 buckets. For your specific scenario, it would likely provide benefits.

When transferring data between Oregon (us-west-2) and North Virginia (us-east-1), which are on opposite sides of the continental United States, Transfer Acceleration can help optimize the network path. This is especially true for your data size range of 10-100 GB, as Transfer Acceleration is ideal for large objects and significant content volumes.

The benefits would be even more pronounced for EC2 instances in Europe accessing your North Virginia bucket, as the geographic distance is much greater. In general, the farther away you are from the S3 Region, the higher the speed improvement you can expect from using Transfer Acceleration.

Transfer Acceleration works by leveraging AWS's globally distributed edge locations (over 50 worldwide) to route data to S3 over an optimized network path. It's particularly effective for:

• Transfers across continents
• Applications with fast internet connections
• Large objects (which applies to your 10-100 GB files)
• Frequent transfers of significant content

Before implementing, you can use the Amazon S3 Transfer Acceleration Speed Comparison tool to test whether it will help your specific use case. This tool will compare accelerated and non-accelerated upload speeds across different regions. You'll only be charged for transfers where Transfer Acceleration actually improves performance.
Sources
Using Amazon S3 Transfer Acceleration to Accelerate Geographically Disparate Data Transfers - Best Practices Design Patterns: Optimizing Amazon S3 Performance
Performance design patterns for Amazon S3 - Amazon Simple Storage Service
Use Amazon S3 Transfer Acceleration to Minimize Latency Caused by Distance - Best Practices Design Patterns: Optimizing Amazon S3 Performance