Is Amazon S3 endpoint accessible from multiple VPC's?

Amazon S3 uses Gateway Endpoints for which traffic has to be originated from the VPC itself and cannot be transitive. This Gateway Endpoint limitation is documented here: https://docs.aws.amazon.com/vpc/latest/userguide/vpce-gateway.html#vpc-endpoints-limitations.

An option to overcome this limitation is to use Amazon EC2 proxy Instances. More detailed information can be found here: https://d0.awsstatic.com/aws-answers/Accessing_VPC_Endpoints_from_Remote_Networks.pdf