How Route 53 and other DNS system works

Hi guys! I have a question about the DNS and Route 53. For example, my company has a public website named www.abc.com. I would like to use Route 53 as my company DNS registrar and save my domain as a record in Route 53. My question is how my user in the world can resolve my domain. I know that most of users use Google DNS 8.8.8.8 as their DNS server. Does Google DNS connect to Route 53 to resolve my DNS query or users have to enter Amazon Route 53 DNS server to resolve my domain. Lastly, how different between using my own public DNS server in my network and using Route 53. I mean the workflow If you know the workflow for all of my situation, please kindly share with me.