REGION UNSUPPORTED, I can not connect to a EC2 instance because the Region (eu-spain) is not supported for IAM instance profile

Hello.

Basically, IAM-related stuff is available in all regions, but what exactly did you try to do that failed?
https://docs.aws.amazon.com/general/latest/gr/iam-service.html

Hi, from your error message, you seem to be logging into your account via AWS IAM Identity Center (IIC)

See list on page: https://docs.aws.amazon.com/general/latest/gr/sso.html

Spain is not in it.

So, you will have to obtain another direct login to this account or work temporarily in another account with direct access if you want to keep working in the region eu-spain.

Re AWS IIC: see https://aws.amazon.com/iam/identity-center/

Didier

Updated image confirmed.
The first image is an IAM Identity Center issue, so I don't think it has anything to do with EC2 instance profiles.
https://docs.aws.amazon.com/singlesignon/latest/userguide/what-is.html

Are instance profiles configured when launching EC2?
Also, do you have AmazonSSMMManagedInstanceCore set for the IAM role you are using for the instance profile?
Otherwise, if EC2 is running on a private subnet, it is necessary to configure a NAT Gateway or Systems Manager VPC endpoint.
https://docs.aws.amazon.com/aws-managed-policy/latest/reference/AmazonSSMManagedInstanceCore.html