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Set the port number to be used for sending mail on the third-party mail server in the outbound rule of the EC2 security group.
https://docs.aws.amazon.com/vpc/latest/userguide/security-group-rules.html#working-with-security-group-rules
In addition, if you wish to use port 25 for sending emails, you must apply to AWS for deactivation by following the procedure in the following document.
https://repost.aws/knowledge-center/ec2-port-25-throttle
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