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Hello,
VPC endpoints can only connect to domains within the same AWS Region.
Reference:
https://docs.aws.amazon.com/opensearch-service/latest/developerguide/vpc-interface-endpoints.html
1
The other reply is correct, but adding to that, all VPC endpoints are regional, because a VPC itself is a regional construct. Being able to create VPC endpoints only in the home region of the resource isn't specific to OpenSearch. Similarly, a VPC endpoint for S3, for example, can only reach S3 buckets in the region of the VPC endpoint.
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