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You can create 1 Application Load Balancer. Create VPC peering between Load Balancer VPC and VPCs in other regions, where your REST API EC2 instances are deployed. Create 3 target groups for your ALB. Each Target group has own EC2 instance (target by IP address)
When all 3 instances are registered under ALB, create 3 rules where you will analyze HTTP headers and route requests to the appropriate EC2 instance
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