You can think of DynamoDB as a web service, as long as you have permissions to access it you will be able to do so over the internet. For that reason, I would first look at the IAM permissions needed to interact with DynamoDB.
For example, lets say you interact with DynamoDB via
API Gateway -> AWS Lambda -> DynamoDB, in this case you would need to ensure the Lambda has permissions to read/write to DynamoDB.
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