By "instance" do you mean EC2 instance?
Have a look at the following link to troubleshoot in case it is EC2: https://aws.amazon.com/premiumsupport/knowledge-center/ec2-linux-resolve-ssh-connection-errors/#:~:text=For%20the%20%E2%80%9CConnection%20timed%20out%E2%80%9D%20error%2C%20verify%20the%20following&text=The%20network%20ACLs%20of%20instance,instance%20and%20the%20SSH%20client.
If question is not related to EC2 instances - can you provide more details
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