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"Single digit ms" latency is the design of availability zones, not regions. While us-east-2 and us-east-1 are closer than other regions in the US, it is highly likely the latency will exceed 10 ms. See https://aws.amazon.com/about-aws/global-infrastructure/regions_az/
The best method to lower latency when accessing RDS between two regions, in my opinion, would be to set up an RDS read replica in the US-East-2 region. Applications in that area could access the database locally for reads, and query latency would be greatly decreased.
If you must use the US-East-1 region's primary database for writes, do so, however, cross-region traffic will increase write latency. The best choice for write-dominant applications in Region 2 would be Aurora Global Database, which provides high-performance inter-region replication, enabling writes in each region and quick, low-latency local reads.
See More: https://docs.aws.amazon.com/AmazonRDS/latest/UserGuide/USER_ReadRepl.html https://docs.aws.amazon.com/AmazonRDS/latest/UserGuide/Concepts.RegionsAndAvailabilityZones.html
